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Sildenafila

Sildenafil is a vasoactive agent used to treat erectile dysfunction and reduce symptoms in patients with pulmonary arterial hypertension (PAH). Sildenafil elevates levels of the second messenger, cGMP, by inhibiting its breakdown via phosphodiesterase type 5 (PDE5). PDE5 is found in particularly high concentrations in the corpus cavernosum, erectile tissue of the penis. It is also found in the retina and vascular endothelium. Increased cGMP results in vasodilation which facilitates generation and maintenance of an erection. The vasodilatory effects of sildenafil also help reduce symptoms of PAH.

Other names for this medication:
Caverta, Intagra, Kamagra, Penegra, Revatio, Silagra, Sildenafil, Sildenafila, Sildenafilo, Sildenafilum, Sildigra, Suhagra, Veega, Zenegra

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Also known as: Sildenafil

Description

Sildenafila comes as tablets that are taken by mouth. You should take Sildenafila according to your doctor’s or healthcare provider’s instructions.

When to take

For most people, it’s recommended that you take Sildenafila as needed, about 1 hour before you plan to have sex. But Sildenafila can actually be taken anywhere from 30 minutes to 4 hours before sexual activity.

It’s important to remember that you shouldn’t take the medication more than once a day.

Taking Sildenafila with food

You can take Sildenafila either with or without food. But if you take it with a meal, the drug may take about an hour longer than usual to start working. This is especially the case if you eat a high-fat meal, such as a cheeseburger with fries.

You don’t need to wait to take Sildenafila if you’ve recently eaten a meal. Just be aware that it might take a bit longer for the drug to work.

It’s also important to remember that if Sildenafila gives you indigestion, taking the drug with food may help to reduce this side effect.

Can Sildenafila be crushed, split, or chewed?

The safety and effectiveness of Sildenafila tablets that are crushed, split, or chewed haven’t been tested. And Sildenafila tablets are meant to be swallowed whole. It’s not known if crushing or chewing the tablets will make them work any differently than usual.

If you have trouble swallowing Sildenafila tablets, you might find it easier to swallow the tablet with different drinks, such as water, juice, or milk. Or talk with your doctor or pharmacist about how else you can take the drug.

If you want to crush, split, or chew Sildenafila tablets, ask your doctor or pharmacist if this is safe to do.

Dosage

Take Viagra exactly as it was prescribed for you. Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended.

Viagra is usually taken only when needed, 30 minutes to 1 hour before sexual activity. You may take it up to 4 hours before sexual activity. Do not take Viagra more than once per day.

Viagra can help you have an erection when sexual stimulation occurs. An erection will not occur just by taking a pill. Follow your doctor's instructions.

During sexual activity, if you become dizzy or nauseated, or have pain, numbness, or tingling in your chest, arms, neck, or jaw, stop and call your doctor right away. You could be having a serious side effect of Viagra.

Overdose

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Side effects

The most common side effects associated with Sildenafila are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Below are the cases in which Viagra is contraindicated in men:

Sildenafil is contraindicated in case the patient is consuming medicines classified under nitrates, organic nitrites and nitric oxide donors. Examples of such medicines include sodium Nitroprusside, amyl nitrite and glyceryl trinitrate.

Sildenafil should not be consumed in cases where sexual activity is prohibited by doctors due to medical conditions affecting the cardiovascular health. Sildenafil will increase the blood flow in this case and as a result heart will exert that may lead to severe complications.

In case of severe hepatic and renal impairment - if an individual with erectile dysfunction suffers from severely affected liver and kidney disorders consumes the sildenafil, there are chances that liver will not be able to process the drug into the bloodstream and kidneys may not excrete the drug as in the normal healthy individual. As a result there can be damage to liver as well as kidneys and lack of excretion will increase side-effects and complications.

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The results demonstrate, under physiological conditions, the operation of a growth factor- and lectin-responsive electron transport system at the cell surface using a cultured human cell line. The present review focuses on efficacy, adverse events, treatment protocols, and mechanisms of action of IVIG, immunoadsorption, and rituximab in the treatment of severe and/or refractory patients with bullous autoimmune diseases. An Arrhenius analysis of the temperature dependent friction over this range yields an effective activation energy of approximately 0.3 eV for the thermally activated stick-slip motion of the probe tip on this surface. Ten individuals with stroke evaluated the games in focused interviews and one individual with chronic stroke completed one month of independent HAMSTER use in the home. Such effects may be physical and emotional and the outcomes can you drink alcohol on plavix may be against the well being of the patient. In experiment 2, lower dose daily infusions of 0.25-4 micrograms PTH per 100 g did not increase bone mass.

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