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Piozone (Glimepiride)

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Piozone is a medication used to treat diabetes mellitus type 2. It is less preferred than Piozone. Use is recommended together with diet and exercise. It is taken by mouth. Piozone takes up to three hours for maximum effect and lasts for about a day.

Other names for this medication:
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Also known as: Glimepiride


Piozone (glimepiride) is an oral diabetes medicine that helps control blood sugar levels.

Piozone is used together with diet and exercise to improve blood sugar control in adults with type 2 diabetes mellitus. This medicine is not for treating type 1 diabetes.

Insulin or other diabetes medicines are sometimes used in combination with Piozone if needed.


Take Generic Piozone tablets orally with breakfast or the first big meal of the day. Do not crush or chew it. Take Generic Piozone at the same time once a day with water. If you want to achieve most effective results do not stop taking Generic Piozone suddenly.


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An Piozone overdose can cause life-threatening hypoglycemia.

Symptoms of severe hypoglycemia include extreme weakness, confusion, tremors, sweating, fast heart rate, trouble speaking, nausea, vomiting, rapid breathing, fainting, and seizure (convulsions).


Store at room temperature below 30 degrees C (86 degrees F) away from moisture and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Piozone are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


You should not use Piozone if you are allergic to glimepiride, sulphonamides, or if you have:

an allergy to sulfa drugs; or diabetic ketoacidosis (call your doctor for treatment).

To make sure Piozone is safe for you, tell your doctor if you have ever had:

heart disease; liver or kidney disease; or an enzyme deficiency called glucose-6-phosphate dehydrogenase deficiency (G6PD).

Piozone may increase your risk of serious heart problems, but not treating your diabetes can also damage your heart and other organs. Talk to your doctor about the risks and benefits of this medicine.

Follow your doctor's instructions about using Piozone if you are pregnant or you become pregnant. Controlling diabetes is very important during pregnancy, and having high blood sugar may cause complications in both the mother and the baby. However, you may need to stop taking Piozone for a short time just before your due date.

Medications similar to glimepiride have caused severe hypoglycemia in newborn babies whose mothers used the medicine near the time of delivery. If you take glimepiride during pregnancy, stop taking this medicine at least 2 weeks before your due date.

If you breastfeed while taking glimepiride, call your doctor if your baby shows signs of hypoglycemia (extreme drowsiness, feeding problems, mottled skin, blue lips, feeling cold or jittery, or having a seizure).

Piozone is not approved for use by anyone younger than 18 years old.

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